Stability studies of ALD-52 and its homologue 1P-LSD.
Journal of forensic sciences May 1, 2023 Shu-Hua Zhang, Angeline S Y Tang, Reenie S L Chin et al. 7 citations
Blotter papers once carried only LSD, but now contain related lysergamides such as ALD-52 and 1P-LSD. When these papers are analyzed by solvent extraction followed by gas chromatography-mass spectrometry, the solvent choice matters: methanol and ethanol cause ALD-52 to convert into LSD during analysis, while isopropyl alcohol prevents that conversion. The hydrolysis happens at the GC injector port and is more pronounced at lower concentrations (0.1 mg/mL). 1P-LSD also hydrolyzes to LSD, but is more stable than ALD-52 because its propanoyl group provides steric hindrance.