Mechanism of lysergic acid diethylamide interference with rabbit antibody biosynthesis
Proceedings of the National Academy of Sciences of the United States of America January 1, 1974 Edward W. Voss, Jeffrey L. Winkelhake 8 citations
Lymphoid cells from hyperimmune rabbits producing antibodies to a hapten, when incubated with d-lysergic acid diethylamide (LSD), synthesized protein at a normal rate. However, the low-molecular-weight protein secreted by these cells had isoelectric points (pI) of 4.9 and 5.2, whereas immune cells not exposed to LSD secreted only 7S IgG molecules with an average pI of about 7.0. This suggests LSD alters the type of protein secreted by these immune cells.