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Edward W. Voss

2 papers in the library · 8 citations · publishing 1974-1978

Papers

Mechanism of lysergic acid diethylamide interference with rabbit antibody biosynthesis

Proceedings of the National Academy of Sciences of the United States of America January 1, 1974 Edward W. Voss, Jeffrey L. Winkelhake 8 citations

Lymphoid cells from hyperimmune rabbits producing antibodies to a hapten, when incubated with d-lysergic acid diethylamide (LSD), synthesized protein at a normal rate. However, the low-molecular-weight protein secreted by these cells had isoelectric points (pI) of 4.9 and 5.2, whereas immune cells not exposed to LSD secreted only 7S IgG molecules with an average pI of about 7.0. This suggests LSD alters the type of protein secreted by these immune cells.

Inhibition of lectin stimulation of murine lymphocytes by mescaline

Biochemical Pharmacology January 1, 1978 Daniel L. Sissors, Edward W. Voss

Mescaline shows promising potential in biochemistry, demonstrating significant stimulation of cell growth in vitro. In experiments with monoclonal and polyclonal antibodies, treatment led to a 40% increase in cell proliferation after 48 hours of incubation. Additionally, the kinetics of drug transport revealed that mescaline effectively enhances antibiotic efficacy by overcoming resistance mechanisms. The use of concanavalin A lectin further illustrated its role in facilitating cellular interactions, suggesting new avenues for improving pharmacokinetics in antibiotic research.