The P3 in ‘ecstasy’ polydrug users during response inhibition and execution
Journal of Psychopharmacology September 1, 2005 Alex Gamma, Daniel Brandeis, Ruven Brandeis et al. 36 citations
People who use ecstasy (MDMA) along with other drugs show reduced P3 brain-wave amplitudes during a task that requires inhibiting a prepared response, compared with non-users. This lower amplitude is consistent with greater neural disinhibition. However, the normal pattern of brain activity shifting forward when inhibiting a response, and the less frontal location of the inhibition-related brain signal, do not point to a fundamental disruption of inhibitory brain mechanisms. The differences became weaker after accounting for age, education, and lifetime cannabis use.