Hippocampal Sharp-Wave Ripples Influence Selective Activation of the Default Mode Network
Current Biology February 20, 2016 Raphael Kaplan, Mohit H. Adhikari, Rikkert Hindriks et al. 127 citations
Hippocampal sharp-wave ripples, brief high-frequency oscillations linked to memory consolidation, are followed by a dramatic increase in fMRI signal within the default mode network (DMN) of anesthetized monkeys. This effect was specific to ripples and did not occur after other hippocampal events or in other resting-state networks. The findings link circuit-level neural dynamics—ripples—to network-level fluctuations in the DMN, providing mechanistic support for the DMN's role in memory consolidation.