Judith Nottage

2 papers in the library · 476 citations · publishing 2010-2012

Papers

Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment

Journal of Psychopharmacology October 5, 2012 Amir Englund, Paul D. Morrison, Judith Nottage et al. 463 citations

Pre-treatment with 600 mg of cannabidiol (CBD) reduced the likelihood of clinically significant psychotic symptoms and paranoia caused by intravenous delta-9-tetrahydrocannabinol (THC, 1.5 mg) in healthy volunteers. Participants who received CBD before THC had lower scores on the State Social Paranoia Scale and smaller declines in episodic memory compared with those who received placebo before THC. The odds of experiencing a clinically significant increase in positive psychotic symptoms were about 78% lower in the CBD group. These results support the view that cannabis products high in THC and low in CBD pose greater mental health risks.

DOI: 10.1177/0269881112460109 Cannabidiol Cannabis Paranoia Placebo +7

Delta-9-Tetrahydrocannabinol Disruption of Time Perception and of Self-Timed Actions

Pharmacopsychiatry July 22, 2010 James Stone, Paul Morrison, Judith Nottage et al. 13 citations

THC impairs subjective time perception and reduces the rate of button pressing in healthy volunteers, but the change in button pressing rate is more closely related to impaired concentration and intoxication than to time perception. The disruption of self-timed actions from THC may arise from a different mechanism than alterations in time perception.

DOI: 10.1055/s-0030-1255030 Time perception Psychology Delta-9-tetrahydrocannabinol Mechanism biology +5