Pharmacopsychiatry
July 22, 2010
James Stone, Paul Morrison, Judith Nottage et al.
13 citations
THC impairs subjective time perception and reduces the rate of button pressing in healthy volunteers, but the change in button pressing rate is more closely related to impaired concentration and intoxication than to time perception. The disruption of self-timed actions from THC may arise from a different mechanism than alterations in time perception.
Schizophrenia bulletin
November 1, 2008
Cécile Henquet, Marta Di Forti, Paul Morrison et al.
Cannabis use is considered a contributory cause of schizophrenia and psychotic illness, but only a small proportion of users develop psychosis. The amount, duration, and strength of cannabis consumption, as well as age at first exposure, partly explain this. Genetic factors likely play a role in both short- and long-term effects on psychosis. This review discusses studies using genetic, epidemiological, experimental, and observational techniques to investigate gene-environment correlation and interaction within the cannabis-psychosis association. Evidence suggests that mechanisms of gene-environment interaction underlie the link, with multiple genetic variations and other environmental factors (e.g., stress) interacting with cannabis to increase psychosis risk. Further research on higher-order interactions is needed.