Cognitive-Affective Neural Plasticity following Active-Controlled Mindfulness Intervention
Journal of Neuroscience October 31, 2012 Micah Allen, Martin Dietz, Karina S. Blair et al. 389 citations
A six-week randomized trial compared mindfulness training to an active control condition in healthy adults. Both groups improved on a response-inhibition task, but only the mindfulness group showed reduced emotional conflict on an affective Stroop task. The mindfulness group also showed greater dorsolateral prefrontal cortex activity during executive processing, suggesting increased use of top-down control. No overall group differences emerged for negative affect-related reaction times or brain responses. However, participants who practiced mindfulness the most showed improved response inhibition and greater recruitment of dorsal anterior cingulate cortex, medial prefrontal cortex, and right anterior insula during negative-valence processing. The findings indicate that mindfulness training engages distinct neural mechanisms at progressive stages and that optimal application may depend on context.