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Roujia Wang

2 papers in the library · publishing 2019-2020

Papers

UHPLC-MS/MS method for simultaneously detecting 16 tryptamines and their metabolites in human hair and applications to real forensics cases.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences November 30, 2020 Yan Shi, Roujia Wang, Shuai Yuan et al.

A rapid UHPLC-MS/MS method was developed to screen 16 tryptamines in hair samples. Twenty milligrams of hair were pulverized and processed, achieving limits of detection from 0.1 to 20 pg/mg and quantitation from 3 to 50 pg/mg. The method was applied to 191 hair samples from suspected tryptamine users; 77 tested positive for 5-MeO-DiPT, while the other 114 showed none of the targeted tryptamines or metabolites. In 34 samples, 5-MeO-DiPT and its metabolites 5-MeO-NiPT, 5-OH-DiPT, and 4-OH-DiPT were detected together. The method demonstrated good accuracy (91-114%), precision, and recovery (85-115%), making it suitable for forensic analysis of tryptamine use.

DOI: 10.1016/j.jchromb.2020.122392 Full text 5-MEO-Dipt Hair analysis Metabolites Tryptamine +1

Application of hair analysis to document illegal 5-methoxy-N,N-dissopropyltrptamine (5-MeO-DiPT) use.

Forensic science international November 1, 2019 Roujia Wang, Ping Xiang, Zhiguo Yu et al.

A new method using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was developed to measure the designer hallucinogen 5-MeO-DiPT in human hair. The method was validated and applied to 106 real cases of suspected users, finding hair concentrations ranging from 0.2 to 7532.5 pg/mg. The technique provides a way to document illegal use of this synthetic tryptamine derivative.

DOI: 10.1016/j.forsciint.2019.109972 Full text 5-MEO-Dipt Hair analysis Uhplc-ms/ms