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Wei Du

Academic Affairs, Tower Health, West Reading, PA 19611, USA.

2 papers in the library · 11 citations · publishing 2024

Papers

Antagonistic interaction between caffeine and ketamine in zebrafish: Implications for aquatic toxicity.

Environmental science and ecotechnology September 1, 2024 Zhenglu Wang, Jindong Xu, Wei Du 6 citations

Caffeine and ketamine, both found in surface waters across Asia, interact in a way that reduces caffeine's harmful effects on zebrafish larvae. Ketamine at concentrations of 10-250 ng L-1 counteracts the hyperactivity and disrupted daily rhythms caused by 2 mg L-1 of caffeine, with the effect depending on dose. Developmental abnormalities in larvae exposed to caffeine drop from 26.7% to 6.7% when ketamine is present. The two chemicals compete for binding sites on the GABA-A receptor, explaining their antagonistic relationship. After seven days of recovery, caffeine's adverse effects persist, while those in the caffeine-plus-ketamine groups lessen, especially at 10 ng L-1 of ketamine. The findings highlight the need to assess risks of co-pollution and suggest that nighttime fish behavior may serve as a sensitive toxicity biomarker.

DOI: 10.1016/j.ese.2024.100437 Full text Ketamine Antagonistic effect Caffeine Gabaergic synapse +4

Alleviating role of ketamine in breast cancer cell-induced osteoclastogenesis and tumor bone metastasis-induced bone cancer pain through an SRC/EGR1/CST6 axis.

BMC cancer December 18, 2024 Xiaomin Zhang, Yanmei Zhang, Wei Du 5 citations

Ketamine suppresses breast cancer cell growth, spread, and the ability of those cells to promote bone-destroying osteoclast activity. In cell lines and a mouse model of bone metastasis, ketamine reduced tumor burden and pain. The drug works by inhibiting the SRC protein, which in turn restores the EGR1/CST6 signaling pathway. Overexpression of SRC blocked ketamine's effects, while restoring EGR1 or CST6 counteracted SRC's harmful actions. The findings indicate that ketamine alleviates bone metastasis and associated pain in breast cancer through this molecular mechanism.

DOI: 10.1186/s12885-024-13290-7 Full text Bone cancer pain Cst6 Egr1 Src +9