Alleviating role of ketamine in breast cancer cell-induced osteoclastogenesis and tumor bone metastasis-induced bone cancer pain through an SRC/EGR1/CST6 axis.
BMC cancer December 18, 2024 Xiaomin Zhang, Yanmei Zhang, Wei Du 5 citations
Ketamine suppresses breast cancer cell growth, spread, and the ability of those cells to promote bone-destroying osteoclast activity. In cell lines and a mouse model of bone metastasis, ketamine reduced tumor burden and pain. The drug works by inhibiting the SRC protein, which in turn restores the EGR1/CST6 signaling pathway. Overexpression of SRC blocked ketamine's effects, while restoring EGR1 or CST6 counteracted SRC's harmful actions. The findings indicate that ketamine alleviates bone metastasis and associated pain in breast cancer through this molecular mechanism.