Short and long term changes in NMDA receptor binding in mouse brain following chronic phencyclidine treatment.
Journal of neural transmission (Vienna, Austria : 1996) January 1, 2007 K A Newell, K Zavitsanou, X-F Huang
Chronic treatment with the NMDA receptor antagonist PCP increased NMDA receptor binding in the mouse hippocampus shortly after the last dose, but after a longer delay widespread reductions in binding occurred, including a 35% reduction in the hippocampus. These findings suggest that the hippocampus is centrally involved in both short- and long-term effects of PCP and that reduced NMDA receptor function may underlie the lasting actions of PCP and PCP-induced psychosis. The long-term delay after chronic PCP treatment more accurately models NMDA hypofunction than the short-term model.