Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine.
The Journal of neuroscience : the official journal of the Society for Neuroscience July 15, 1998 B Adams, B Moghaddam
PCP and its analog ketamine produce a behavioral syndrome that models some aspects of schizophrenia. Previously, the psychotomimetic and cognitive-impairing effects were attributed mainly to the corticolimbic dopamine system. This study measured dopamine and glutamate efflux in the prefrontal cortex and nucleus accumbens of rodents after PCP injection, using microdialysis. PCP increased both dopamine and glutamate levels. Dopamine remained elevated above baseline 2.5 hours after injection, yet locomotor activity returned to baseline in less than 2 hours, and working memory impairment (measured by a delayed alternation task) was only evident up to 60 minutes after injection.