The Impact of Preoperative Low-Dose Esketamine and Dexmedetomidine Nasal Administration on the Emergence Delirium in Children Undergoing Fiber Bronchoscopy: A Prospective Randomized Controlled Trial.
Clinical neuropharmacology Wei Xie, Le Wang, Zhe Peng et al. 6 citations
Preoperative nasal administration of low-dose esketamine or dexmedetomidine reduces emergence delirium after pediatric fiberoptic bronchoscopy. In a randomized trial of 126 children aged 1–6 years, emergence delirium occurred in 7.14% of those given 1.0 mg/kg esketamine and 18.6% of those given 1.0 μg/kg dexmedetomidine, compared with 48.78% in the saline control group. Both drugs also lowered postoperative pain intensity. Dexmedetomidine prolonged the time to awaken and open eyes in the recovery unit, while hemodynamics, oral secretions, and recovery-stay duration did not differ among groups.