Biobricks of Microbial Natural Product Syntheses, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Jena, Germany.
2 papers in the library · 19 citations · publishing 0-2024
By deleting genes involved in L-tryptophan catabolism, psilocybin production was increased fivefold in baker's yeast and tenfold in the filamentous fungus Aspergillus nidulans. Process optimization in A. nidulans batch cultures yielded a final psilocybin titre of 267 mg/L with a space-time-yield of 3.7 mg/L/h. The engineered strain demonstrates suitability as a production chassis for psilocybin and other tryptamine-derived pharmaceuticals.
Preoperative nasal administration of low-dose esketamine or dexmedetomidine reduces emergence delirium after pediatric fiberoptic bronchoscopy. In a randomized trial of 126 children aged 1–6 years, emergence delirium occurred in 7.14% of those given 1.0 mg/kg esketamine and 18.6% of those given 1.0 μg/kg dexmedetomidine, compared with 48.78% in the saline control group. Both drugs also lowered postoperative pain intensity. Dexmedetomidine prolonged the time to awaken and open eyes in the recovery unit, while hemodynamics, oral secretions, and recovery-stay duration did not differ among groups.