Mao-Liang Chen

Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231016, Taiwan.

2 papers in the library · 1 citation · publishing 2025-2026

Papers

Gastrodin Mitigates Ketamine-Induced Inhibition of F-Actin Remodeling and Cell Migration by Regulating the Rho Signaling Pathway.

Biomedicines March 6, 2025 Ping-Cheng Shih, I-Shiang Tzeng, Yi-Chyan Chen et al. 1 citation

Gastrodin, a compound from the traditional herbal medicine Gastrodia elata, counteracts ketamine-induced disruptions in Rho signaling, cytoskeletal dynamics, and cell migration. In B35 and C6 cells, gastrodin reversed ketamine's effects on cell mobility inhibition, F-actin condensation, and the modulation of Rho pathway proteins including RhoGDI1, RhoA, CDC42, Rac1, ROCK1, NWASP, MLC2, PFN1, and cofilin-1. Similar modulations of Rho signaling were observed in the prefrontal cortex of Sprague Dawley rats. These findings suggest gastrodin may act as a comprehensive regulator of cellular signaling, with potential implications for neuronal function and cancer metastasis.

DOI: 10.3390/biomedicines13030649 Full text Ketamine F-actin Gastrodia elata Rho signaling +7

Biological variations in ketamine sensitivity: insights from hyperlocomotion to psychotomimetic features in genetically diverse mouse strains.

Psychiatry research April 1, 2026 Wen-Huei Siao, Tzong-Shi Wang, Liang-Chun Wang et al.

Ketamine, a drug that blocks NMDA receptors and produces schizophrenia-like effects, causes different behavioral responses depending on the mouse strain and dose. Adolescent mice from four strains—C57BL/6J, DBA, BALB/c, and 129S1—received ketamine injections of 0, 25, or 50 mg/kg, and their movement in an open field was tracked. Before and after treatment, locomotor activity varied significantly among strains, with C57BL/6J mice most active and 129S1 mice least active. Ketamine dose-dependently increased movement in C57BL/6J mice, caused brief excitation in DBA mice at 25 mg/kg, delayed excitation in BALB/c mice at 50 mg/kg, and minimal changes in 129S1 mice. These findings demonstrate that genetic background and dose modulate ketamine sensitivity during adolescence.

DOI: 10.1016/j.psychres.2026.116995 Full text Animal model Genetic diversity Ketamine sensitivity Nmda receptor hypofunction +1