Gastrodin Mitigates Ketamine-Induced Inhibition of F-Actin Remodeling and Cell Migration by Regulating the Rho Signaling Pathway.
Biomedicines March 6, 2025 Ping-Cheng Shih, I-Shiang Tzeng, Yi-Chyan Chen et al. 1 citation
Gastrodin, a compound from the traditional herbal medicine Gastrodia elata, counteracts ketamine-induced disruptions in Rho signaling, cytoskeletal dynamics, and cell migration. In B35 and C6 cells, gastrodin reversed ketamine's effects on cell mobility inhibition, F-actin condensation, and the modulation of Rho pathway proteins including RhoGDI1, RhoA, CDC42, Rac1, ROCK1, NWASP, MLC2, PFN1, and cofilin-1. Similar modulations of Rho signaling were observed in the prefrontal cortex of Sprague Dawley rats. These findings suggest gastrodin may act as a comprehensive regulator of cellular signaling, with potential implications for neuronal function and cancer metastasis.