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Mitchell B Liester

Department of Psychiatry, University of Colorado School of Medicine, Colorado Springs, USA.

2 papers in the library · 2 citations · publishing 2024-2025

Papers

The Role of Cells in Encoding and Storing Information: A Narrative Review of Cellular Memory.

Cureus November 1, 2024 Ana I Flores, Mitchell B Liester 2 citations

Memory involves encoding, storing, and retrieving information, and recent research suggests it extends beyond the brain to include body-based and cellular mechanisms. Synaptic changes in the hippocampus are crucial for memory consolidation, but somatic memory shows how sensory and traumatic experiences are stored implicitly. Studies indicate that memories can be encoded and stored in cells and may be transferred between individuals through organ transplantation. Observations in organisms without nervous systems, such as bacteria, fungi, and plants, expand traditional memory concepts. This review compiles findings across disciplines to build a framework explaining cellular processes in memory retention and transfer, though critical gaps remain in understanding how cellular memory interfaces with neural systems.

Low-Dose Sublingual Ketamine for the Treatment of Raynaud's Phenomenon.

Cureus January 1, 2025 Mitchell B Liester

A woman with primary Raynaud's phenomenon experienced significant symptom improvement while receiving low-dose sublingual ketamine for treatment-resistant depression. Ketamine, an FDA-approved anesthetic, has vasodilatory properties that may enhance blood flow and reduce vascular constriction. This case report suggests that ketamine could be a safe and inexpensive treatment for Raynaud's phenomenon, warranting further research.