Photothermal Desorption and Reagent-Assisted Low-Temperature Plasma Ionization Miniature IT-MS/MS for On-Site Analysis of Illicit Drugs in Saliva and Urine.
Analytical chemistry February 11, 2025 Yun Wu, Mei Li, Ruidong Liu et al. 6 citations
A new portable mass spectrometry device, PDRA-LTP-ITMS, can detect illicit drugs in saliva or urine within 5 seconds using only 10 microliters of sample. The method improves sensitivity up to 10-fold compared to some other techniques and achieves detection limits for MDMA, MDA, methamphetamine, amphetamine, ketamine, and cocaine ranging from 4.5 to 20 picograms per microliter in saliva, meeting Chinese national standards. The device's performance approaches that of a high-end laboratory mass spectrometer, offering a rapid on-site tool for identifying drug-impaired drivers.