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Jiao Luo

2 papers in the library · 2 citations · publishing 2024-2025

Papers

Effects of Esketamine on Postoperative Cognitive Function in Elderly Patients Undergoing Pulmonary Lobectomy: A Randomised, Single-Blind Controlled Clinical Trial

Actas Españolas de Psiquiatría December 17, 2025 Xueping Li, Haoping Mao, Jiao Luo et al. 1 citation

In elderly patients (aged 65-75) undergoing pulmonary lobectomy with incision, intraoperative esketamine (0.3 mg/kg/h) was associated with a lower incidence of postoperative cognitive dysfunction on days 1 and 3 after surgery compared to remifentanil. The esketamine group also showed higher serum Aβ42/40 levels and lower tau levels on day 1 postoperatively, along with more stable heart rate, mean arterial pressure, and lower pain scores at the end of surgery. No significant difference in postoperative delirium or adverse events was observed between groups. The findings suggest esketamine may reduce postoperative cognitive decline without increasing safety risks.

DOI: 10.62641/aep.v53i6.2044 Medicine Clinical trial Cognition Anesthesia +1

Effect of esketamine on postoperative quality of recovery in patients undergoing arthroscopic rotator cuff repair: protocol for a prospective, randomized, double-blind study.

Trials December 4, 2024 Qirong Sun, Jiao Luo, Shijia Zhang et al. 1 citation

Early postoperative pain and neurological dysfunction impair recovery after arthroscopic rotator cuff repair. Esketamine, an NMDA receptor antagonist, may reduce opioid use, inflammation, and protect nerves. This single-center, randomized controlled trial will enroll 234 patients undergoing arthroscopic rotator cuff repair, assigning them to general anesthesia with one of two doses of esketamine or saline. The primary outcome is quality of early recovery measured by the QoR-15 scale on postoperative day 1. Secondary outcomes include QoR-15 scores on day 3, remifentanil consumption, vasoactive drug use, cerebral desaturation, pain scores, delirium, and adverse events. The study aims to assess whether esketamine mitigates effects of controlled hypotension on cerebral oxygen saturation and postoperative delirium.

DOI: 10.1186/s13063-024-08600-0 Full text Esketamine Controlled hypotension Early recovery quality Anesthesia anaesthesia +7