The immune regulatory mechanism of ketamine-induced psychiatric disorders: A new perspective on drug-induced psychiatric symptoms.
Progress in neuro-psychopharmacology & biological psychiatry January 10, 2025 Peipei Wang, Junmei Hu, Congliang Chen et al. 2 citations
Ketamine, a psychoactive substance strictly regulated by international drug conventions, is classified as a new type drug due to its excitatory, hallucinogenic, or inhibitory effects. The immune regulatory mechanism is the most prominent among several theories explaining ketamine-induced psychiatric symptoms. Recent research highlights the interaction between the immune system and nervous system in neuropsychiatric disorders, with peripheral lymphocyte infiltration into the central nervous system as an early hallmark. This article provides a comprehensive overview of pathophysiological processes in psychiatric disorders, including those from ketamine, covering nerve damage, central immune alterations, and peripheral immune regulation. It emphasizes the crosstalk between peripheral and central immune systems in the onset and progression of psychiatric diseases, offering fresh perspectives on mechanisms, diagnosis, and therapeutic strategies for drug abuse-related mental disorders.