The amino acid metabolism pathway of peripheral T lymphocytes and ketamine-induced schizophrenia-like phenotype.
Journal of psychiatry & neuroscience : JPN January 1, 2024 Peipei Wang, Linzhi Jiang, Junmei Hu et al. 1 citation
In a mouse model of schizophrenia induced by ketamine, the number of peripheral CD3+ T cells increased. Analysis of metabolites in these immune cells and in plasma showed that amino acid metabolism was substantially altered, with elevated levels of glycine, alanine, asparagine, and aspartic acid. The precise amino acid metabolism pathway driving the schizophrenia-like phenotype has not yet been identified. The findings suggest that the metabolic profile of peripheral immune cells could provide biomarkers for diagnosing and treating psychiatric diseases.