Drug design, development and therapy
January 1, 2024
Bo-Ran Deng, Yang Zhang, Zi-Feng Xie et al.
18 citations
In elderly patients undergoing painless colonoscopies, a combination of remimazolam and esketamine causes fewer drops in blood pressure and other hemodynamic complications than propofol plus esketamine. In a randomized trial with 754 patients, hypotension occurred in 9.78% of those given remimazolam-esketamine versus 23.57% in the propofol-esketamine group. The remimazolam group also had lower rates of sinus tachycardia, sinus bradycardia, and less need for blood-pressure-supporting drugs. Both sedative regimens achieved 100% sedation success, but the remimazolam combination led to a longer time to fall asleep yet faster recovery, along with less respiratory depression and injection pain. The findings indicate remimazolam with esketamine provides superior hemodynamic stability and safety for this population.
International journal of psychology : Journal international de psychologie
April 1, 2025
Rong Wang, Jingyi Zhou, Yang Zhang et al.
3 citations
Appreciative joy—taking delight in others' happiness—and gratitude are related but distinct emotions. A cross-sectional survey of adults found a moderate positive correlation between the two, and gratitude partly explained how appreciative joy relates to subjective well-being. A randomized controlled trial tested four weeks of appreciative joy meditation training. At a one-month follow-up, the training increased both appreciative joy and gratitude, and changes in gratitude were driven by changes in appreciative joy. Although subjective well-being improved immediately after the training, the data did not confirm that appreciative joy or gratitude caused that improvement. The findings clarify how Buddhist meditation practices may boost well-being through gratitude.
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
March 20, 2025
Congli Zhang, Yan Yan, Junjie Ma et al.
1 citation
In a double-blind randomized trial, 82 frail elderly patients undergoing thoracoscopic radical resection of lung cancer received either intravenous esketamine or a placebo (normal saline) during surgery. Those given esketamine had significantly lower depression scores (HAMD-17) at 7 and 30 days after surgery, indicating less postoperative depression. They also reported better sleep quality in the first week and showed higher scores on a cognitive function test (MMSE) in the first month. Esketamine was associated with higher levels of serum BDNF and 5-HT, lower levels of S100β and NSE, reduced use of anesthetic drugs, fewer side effects like nausea and hyperalgesia, and shorter stays in the recovery room and hospital. Esketamine appears to improve postoperative depressive state, sleep, and cognitive function in this vulnerable group.