The impact of ketamine on emergency rapid sequence intubation: a systematic review and meta-analysis.
BMC emergency medicine September 27, 2024 Qinxue Hu, Xing Liu, Tao Xu et al. 3 citations
Ketamine compared with other sedatives during rapid sequence intubation (RSI) in critically ill patients shows no significant difference in in-hospital mortality, physiological function, or adverse events. A systematic review and meta-analysis of 15 studies (5 randomized controlled trials and 10 cohort studies) involving 16,807 participants found no overall mortality benefit (odds ratio 0.90, 95% confidence interval 0.72 to 1.12). Low-quality evidence suggests ketamine may reduce mortality within the first seven days of hospitalization (odds ratio 0.42, 95% confidence interval 0.19 to 0.93) but may also prolong intensive care unit stay (mean difference -0.71 days free of ICU at day 28, 95% confidence interval -1.38 to -0.05).