Molecular neurobiology
February 1, 2025
Na Hu, Yujie Zheng, Xueru Liu et al.
7 citations
Circular RNAs (circRNAs) are abundant in the central nervous system and linked to depression. In a mouse model of depression (chronic unpredictable mild stress), a single intravenous dose of esketamine (5 mg/kg) reduced the expression of circKat6b in hippocampal astrocytes. Overexpressing circKat6b in the hippocampus weakened esketamine's antidepressant effects. Molecular analyses revealed that circKat6b overexpression increased stat1 and p-stat1 expression in astrocytes, and reversed esketamine's suppression of p-stat1. The findings suggest esketamine's antidepressant action may involve lowering circKat6b in hippocampal astrocytes.
BMC psychiatry
June 4, 2025
Yuekun Wu, Yue Ban, Guoliang Pan et al.
6 citations
An 8-week online mindfulness-based stress reduction (MBSR) program reduced symptoms of depression and anxiety among psychiatric healthcare workers in Shenyang, China. In a randomized controlled trial with 135 participants who completed the intervention, those in the online MBSR group showed lower emotional suppression, fewer depression symptoms, and fewer anxiety symptoms compared with a waitlist control group. The reduction in emotional suppression partly explained the improvement in depression and anxiety symptoms, suggesting that online MBSR may work by decreasing emotional suppression.
PloS one
January 1, 2025
Wei Wang, Dan Wang, Li Liu et al.
3 citations
Methamphetamine was the most consumed drug in four cities of Guangdong Province, with consumption ranging from 65 to 223 mg per 1000 inhabitants per day, followed by heroin (19-55 mg/1000 inh/d), codeine (7-20 mg/1000 inh/d), and ketamine (1-13 mg/1000 inh/d). Prevalence rates of methamphetamine, heroin, and ketamine across the cities were 0.149%-0.411%, 0.003%-0.019%, and 0.003%-0.196%, respectively. Between 2023 and 2024, heroin prevalence showed a downward trend, while methamphetamine and ketamine prevalence increased. Cocaine was detected in only two wastewater treatment plants, and MDMA in two separate plants. The analysis of wastewater samples from 67 treatment plants over one year identified six of ten monitored illicit drugs.
BMC emergency medicine
September 27, 2024
Qinxue Hu, Xing Liu, Tao Xu et al.
3 citations
Ketamine compared with other sedatives during rapid sequence intubation (RSI) in critically ill patients shows no significant difference in in-hospital mortality, physiological function, or adverse events. A systematic review and meta-analysis of 15 studies (5 randomized controlled trials and 10 cohort studies) involving 16,807 participants found no overall mortality benefit (odds ratio 0.90, 95% confidence interval 0.72 to 1.12). Low-quality evidence suggests ketamine may reduce mortality within the first seven days of hospitalization (odds ratio 0.42, 95% confidence interval 0.19 to 0.93) but may also prolong intensive care unit stay (mean difference -0.71 days free of ICU at day 28, 95% confidence interval -1.38 to -0.05).