Frontiers in Psychiatry
November 11, 2022
Binyu Teng, Dan Wang, Conghui Su et al.
38 citations
A Chinese translation of the Multidimensional Assessment of Interoceptive Awareness, Version 2 (MAIA-2) was developed and tested in 627 participants. Exploratory factor analysis yielded a 7-factor model after removing 6 items, and confirmatory factor analysis showed good model fit. The total scale had a Cronbach's alpha of 0.822, with subscale alphas ranging from 0.656 to 0.838. Convergent validity was supported by correlations with the Five-Facet Mindfulness Questionnaire (r = −0.342 to 0.535), and discriminant validity by negative correlations with trait anxiety (r = −0.352 to −0.080). The Chinese version is a valid and reliable tool for assessing interoceptive awareness in Chinese populations.
British journal of anaesthesia
May 28, 2025
Jia Huo, Huiming Li, Dan Wang et al.
4 citations
Orexin promotes arousal from general anaesthesia, but the mechanisms are unclear. The nucleus accumbens (NAc), a target of orexin neurons, helps regulate consciousness. During isoflurane anaesthesia, orexinergic afferents in the NAc were wake-active. Optogenetic activation of these terminals prolonged induction time, shortened emergence time, and reduced the burst suppression ratio from 67.4% to 14.5% during 1.4 vol% isoflurane anaesthesia. Microinjection of orexin-A into the NAc promoted arousal. Orexin-1 receptors were expressed mainly in NAc D1 receptor-positive neurons. Activation increased D1R+ neuron firing from 0.77 to 2.53 spikes per second and restored NAc-to-frontal cortex coherence. Orexin restores communication between the NAc and frontal cortex by upregulating D1R+ neuron activity, thereby promoting arousal from isoflurane anaesthesia.
Analytical chemistry
April 29, 2025
Zhongbao Han, Zhongyu Zhao, Meiyun Pan et al.
3 citations
A new method for quickly detecting illicit drugs in biological fluids uses paper-based sample collection combined with ultrasonic desorption and low-temperature plasma ionization mass spectrometry. Optimized with ketamine, the technique achieves detection limits of 10 to 20 ng per mL, linear ranges with R² above 0.99, and recovery rates over 91% in complex fluids. It performs reliably even with drug mixtures and under varied storage conditions. Analysis takes only 3 seconds, making it suitable for high-throughput point-of-care testing and forensic screening.
PloS one
January 1, 2025
Wei Wang, Dan Wang, Li Liu et al.
3 citations
Methamphetamine was the most consumed drug in four cities of Guangdong Province, with consumption ranging from 65 to 223 mg per 1000 inhabitants per day, followed by heroin (19-55 mg/1000 inh/d), codeine (7-20 mg/1000 inh/d), and ketamine (1-13 mg/1000 inh/d). Prevalence rates of methamphetamine, heroin, and ketamine across the cities were 0.149%-0.411%, 0.003%-0.019%, and 0.003%-0.196%, respectively. Between 2023 and 2024, heroin prevalence showed a downward trend, while methamphetamine and ketamine prevalence increased. Cocaine was detected in only two wastewater treatment plants, and MDMA in two separate plants. The analysis of wastewater samples from 67 treatment plants over one year identified six of ten monitored illicit drugs.
Advanced Science
September 25, 2025
Ye Wang, Lei Liu, Jinghao Wang et al.
2 citations
Early administration of S-Ketamine (on day 1) after trauma significantly improves PTSD symptoms in rodent models, particularly impaired fear extinction, while late administration (day 7) does not. The firing and burst rates of dopamine neurons in the ventral tegmental area (VTA) decrease after PTSD modeling and are restored only by early S-Ketamine. These VTA dopamine neurons respond to conditioned stimuli and help replace aversive memory encoding during fear extinction. Inhibiting the VTA-to-orbitofrontal cortex (OFC) pathway blocks S-Ketamine's therapeutic effect. A non-invasive brain stimulation targeting the OFC sensitizes cortical dopaminergic transmission and extends the effective time window of S-Ketamine for anti-PTSD treatment.
Neuroscience research
July 1, 2025
Kaixi Li, Nan Li, Yuanyuan Chen et al.
1 citation
Three synthetic tryptamines—AMT, 5-MeO-AMT, and 5-MeO-DiPT—alter levels of dopamine and serotonin and their metabolites in specific rat brain regions, including the prefrontal cortex, nucleus accumbens, dorsolateral striatum, and hippocampus. The effects vary by brain region and compound, with dopamine and serotonin systems playing key roles. These findings provide insight into the neurochemical actions of tryptamine hallucinogens.
Behavioural pharmacology
July 7, 2025
Kaixi Li, Nan Li, Yuanyuan Chen et al.
Three synthetic tryptamines—AMT, 5-MeO-AMT, and 5-MeO-DiPT—showed acute toxic effects, reduced movement, and triggered head-twitch responses (a sign of hallucinogenic-like behavior) in mice. Pretreatment with a low dose of M100907, a 5-HT2A receptor antagonist, blocked the head-twitch responses caused by all three substances. The findings indicate these compounds are toxic, inhibit locomotor activity, and have hallucinogenic properties, providing experimental data to support future regulation and mechanistic research.