Rapid Screening of Illicit Drugs from Biofluid via Dried Blood/Urine Spot and Ultrasonic Desorption-Assisted Low-Temperature Arc Plasma Ionization Mass Spectrometry.
Analytical chemistry April 29, 2025 Zhongbao Han, Zhongyu Zhao, Meiyun Pan et al. 3 citations
A new method for quickly detecting illicit drugs in biological fluids uses paper-based sample collection combined with ultrasonic desorption and low-temperature plasma ionization mass spectrometry. Optimized with ketamine, the technique achieves detection limits of 10 to 20 ng per mL, linear ranges with R² above 0.99, and recovery rates over 91% in complex fluids. It performs reliably even with drug mixtures and under varied storage conditions. Analysis takes only 3 seconds, making it suitable for high-throughput point-of-care testing and forensic screening.