Myelin oligodendrocyte glycoprotein antibody-associated cerebral cortical encephalitis with super-refractory status epilepticus.
Brain & development November 1, 2024 Yayoi Shide-Moriguchi, Naohiro Yamamoto, Ichiro Kuki et al. 5 citations
A 9-year-old boy with fever, headache, and altered consciousness developed super-refractory status epilepticus due to myelin oligodendrocyte glycoprotein antibody-associated cerebral cortical encephalitis (MOG-CCE). Seizures were initially controlled with high-dose thiopental but recurred upon dose reduction, and long-term thiopental caused adverse effects. Continuous infusion of ketamine and intrathecal dexamethasone therapy promptly arrested the seizures. The patient tested positive for anti-MOG antibodies in cerebrospinal fluid and serum. After three courses of intravenous methylprednisolone pulse therapy followed by a 6-month taper of oral prednisolone, he had no relapse for 6 months. Ketamine and intrathecal dexamethasone may be useful for seizure control in MOG-CCE with super-refractory status epilepticus.