Cannabidiol or ketamine for preventing the impact of adolescent early drug initiation on voluntary ethanol consumption in adulthood.
Frontiers in pharmacology January 1, 2024 Carles Colom-Rocha, Cristian Bis-Humbert, M Julia García-Fuster 3 citations
Adolescent exposure to ethanol, alone or combined with cocaine, increases voluntary ethanol consumption in adult male and female rats, but does not cause lasting negative affect. Cocaine alone has no effect on later ethanol intake. In rats exposed to adolescent ethanol, adult treatment with cannabidiol reduces ethanol consumption in both sexes, while ketamine reduces it only in females. These findings identify two potential therapeutic interventions to mitigate the long-term impact of early drug initiation.