JMIR mHealth and uHealth
May 3, 2023
Ying He, Zhijie Tang, Guozhen Sun et al.
21 citations
A brain-computer interface-based mindfulness meditation app, delivered alongside radiofrequency catheter ablation for atrial fibrillation, significantly reduced patients' pain, anxiety, and fatigue compared to conventional care alone. In a randomized trial of 84 patients, those using the app reported lower numeric rating scale scores (mean 4.6 vs 5.7), lower State Anxiety Inventory scores (mean 36.7 vs 42.3), and lower Brief Fatigue Inventory scores (mean 3.4 vs 4.7). The app also reduced the dose of fentanyl needed during the procedure (mean 3.96 vs 4.85 mcg/kg), though heart rate, blood pressure, oxygen levels, and other sedative use did not differ between groups.
Biochemical and biophysical research communications
September 17, 2024
Jia-Wei Zhang, Hai-Qian Zhou, Zhen Zhu et al.
7 citations
Adolescent ketamine abuse causes lasting deficits in cognition and social behavior by reducing excitatory synapses on parvalbumin (PV) inhibitory neurons in the medial prefrontal cortex (mPFC), while sparing excitatory pyramidal neurons. In rats given sub-chronic ketamine during early adolescence, the density of these synapses remained lower into adulthood, leading to hyperexcitability, impaired working memory, and reduced social interaction compared to controls. Bioinformatic analysis revealed decreased expression of a gene co-expression module (M1) critical for inhibitory neuron synapse development. The findings suggest that adolescent ketamine exposure irreversibly disrupts synaptic development, pointing to potential therapeutic targets.
Pain and therapy
December 1, 2023
Shuanghong Chen, Xubin Gao, Ting Shi et al.
6 citations
A culturally adapted mindfulness-based stress reduction (MBSR) program for Chinese adults with chronic pain led to greater short-term reductions in pain catastrophizing compared with treatment as usual, though the effect was not maintained at three months. Among participants who completed the program, MBSR also reduced pain interference and perceived stress. Brain scans showed that both groups had decreased regional homogeneity in the frontal lobe, while increased activity in the cerebellum anterior lobe was unique to the MBSR group. The findings suggest modest benefits of a culturally adapted MBSR program for certain pain-related outcomes in Chinese adults with chronic pain.