N-tert-butoxycarbonyl-methylenedioxymethamphetamine, an methylenedioxymethamphetamine derivative, exhibits rewarding and reinforcing effects by increasing dopamine levels.
Behavioral neuroscience October 1, 2024 Dong-Hyun Youn, Cheolmin Jo, Jin Mook Kim et al. 1 citation
A new chemical, t-BOC-3,4-MDMA, is a modified form of MDMA that can evade detection in the illicit drug market and can be converted into the controlled substance MDMA. In mice, a 5 mg/kg dose of t-BOC-3,4-MDMA significantly altered place preference, indicating rewarding effects, and at 0.5 mg/kg/infusion it induced drug-taking behavior in self-administration tests. Microdialysis in rats showed that the chemical increased dopamine levels in the striatum. These findings suggest that t-BOC-3,4-MDMA has potential for misuse.