Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety.
2 papers in the library · 5 citations · publishing 2022-2024
Deschloroketamine (10 mg/kg) and diphenidine (10-60 mg/kg) produced increased locomotor activation and stereotypy similar to ketamine (10 mg/kg) in mice. Both substances increased preference for the drug-paired compartment in conditioned place preference testing, indicating rewarding effects. In self-administration tests, deschloroketamine (1 mg/kg/infusion) increased active lever presses and infusions, suggesting reinforcing effects, whereas diphenidine (1, 2 mg/kg/infusion) did not alter these measures. Both compounds increased dopamine levels in PC-12 cells. The data suggest deschloroketamine may have both rewarding and reinforcing effects, while diphenidine only induced rewarding effects.
A new chemical, t-BOC-3,4-MDMA, is a modified form of MDMA that can evade detection in the illicit drug market and can be converted into the controlled substance MDMA. In mice, a 5 mg/kg dose of t-BOC-3,4-MDMA significantly altered place preference, indicating rewarding effects, and at 0.5 mg/kg/infusion it induced drug-taking behavior in self-administration tests. Microdialysis in rats showed that the chemical increased dopamine levels in the striatum. These findings suggest that t-BOC-3,4-MDMA has potential for misuse.