A single low dose of 1cp-LSD (5 µg, or 0.38 µg/kg) was given orally to a 13-year-old mixed-breed dog with lifelong separation anxiety. For the first two hours the dog remained equally anxious in response to anxiety-inducing stimuli, but after that point its behavior showed a significant change with no or only mild signs of anxiety. The trial lasted five and a half hours and produced no adverse effects; the dog showed no signs of a psychedelic experience. The authors conclude that 1cp-LSD was safe and effectively reduced the dog's anxiety.
A 13-year-old female dog with severe separation anxiety received 5 µg of 1cp-LSD every three days for a month. The dog's anxiety score dropped from 29 (severe) to 14 (moderate) after treatment, with less destructive behavior and shorter vocalizations. One month later, improvement mostly held, though vocalization frequency increased. The lack of a control group means the observed changes could stem from the drug, owner expectations, or natural behavior shifts. Blinded studies with more dogs are needed to confirm whether microdosing 1cp-LSD helps canine anxiety.