Veterinary research communications
December 1, 2024
Luis Alberto Henríquez-Hernández, Ignacio García-Serrano, Domingo J Quintana-Hernández et al.
4 citations
A single low dose of 1cp-LSD (5 µg, or 0.38 µg/kg) was given orally to a 13-year-old mixed-breed dog with lifelong separation anxiety. For the first two hours the dog remained equally anxious in response to anxiety-inducing stimuli, but after that point its behavior showed a significant change with no or only mild signs of anxiety. The trial lasted five and a half hours and produced no adverse effects; the dog showed no signs of a psychedelic experience. The authors conclude that 1cp-LSD was safe and effectively reduced the dog's anxiety.
Veterinary medicine and science
July 1, 2025
Elisa Hernández-Álvarez, Lucas F Borkel, Jaime Rojas-Hernández et al.
3 citations
A 13-year-old female dog with severe separation anxiety received 5 µg of 1cp-LSD every three days for a month. The dog's anxiety score dropped from 29 (severe) to 14 (moderate) after treatment, with less destructive behavior and shorter vocalizations. One month later, improvement mostly held, though vocalization frequency increased. The lack of a control group means the observed changes could stem from the drug, owner expectations, or natural behavior shifts. Blinded studies with more dogs are needed to confirm whether microdosing 1cp-LSD helps canine anxiety.
Animals : an open access journal from MDPI
December 19, 2025
Elisa Hernández-Álvarez, Andrea Acosta-Dacal, Octavio P Luzardo et al.
1 citation
A proposed study will test whether low doses of 1cp-LSD, a legal LSD analogue, can help manage chronic pain in dogs with osteoarthritis. About 24 dogs will receive intermittent, sub-perceptual doses of the drug or a placebo over 30 days while continuing standard pain medication. Caregivers will not know which treatment their dog receives. Pain will be measured using the Canine Brief Pain Inventory and caregiver reports, including a questionnaire on treatment expectations. The study expects pain scores to decrease in treated dogs, possibly influenced by caregiver expectations. Limitations include a small sample size and lack of established dosing.
Veterinary sciences
January 19, 2026
Elisa Hernández-Álvarez, Cristina Canino-Quijada, Sira Roiz et al.
Giving shelter dogs a low dose of 1cp-LSD (a legal LSD-like compound) alongside behavioral therapy improves their sociability, calmness, and positive emotional reactivity more than either treatment alone. Twenty dogs were randomly assigned to receive the drug, ethological intervention, both, or neither. The combined treatment produced benefits that lasted for three weeks after the sessions ended. These results offer early evidence that integrating low-dose psychedelics with behavioral therapy could help reduce stress and anxiety in shelter dogs, though larger studies are needed to confirm safety and effectiveness.
PloS one
January 1, 2026
Diego Castellano-Ramírez, Elisa Hernández-Álvarez, Lucas F Borkel et al.
A survey of 325 medical and nursing students at a Spanish university found cautiously optimistic views toward psychedelic-assisted therapy, though concerns persist. Women reported lower perceived knowledge about psychedelics, while older students showed greater openness to their therapeutic potential. Medical students had higher perceived knowledge and stronger agreement with therapeutic applications than nursing students, who more strongly linked psychedelic use to psychiatric risk. Students who had personally used psychedelics were more supportive of legalization and therapeutic use. Formal education on psychedelics was associated with more favorable attitudes and increased knowledge, suggesting that training may reduce stigma and support evidence-based policy.