Giving shelter dogs a low dose of 1cp-LSD (a legal LSD-like compound) alongside behavioral therapy improves their sociability, calmness, and positive emotional reactivity more than either treatment alone. Twenty dogs were randomly assigned to receive the drug, ethological intervention, both, or neither. The combined treatment produced benefits that lasted for three weeks after the sessions ended. These results offer early evidence that integrating low-dose psychedelics with behavioral therapy could help reduce stress and anxiety in shelter dogs, though larger studies are needed to confirm safety and effectiveness.
Adding a low-dose ketamine infusion to xylazine sedation in horses undergoing standing surgery did not significantly reduce the amount of xylazine needed, but it did produce deeper sedation. In a randomized trial with 51 horses, those receiving xylazine plus ketamine required a median xylazine dose of 0.8 mg/kg/h compared to 0.9 mg/kg/h for xylazine alone, a difference that was not statistically significant. Horses given ketamine achieved deeper sedation scores without increased ataxia or changes in surgical conditions. Cardiorespiratory variables remained stable in both groups, and no adverse events occurred. The findings suggest ketamine can enhance sedation depth without reducing xylazine requirements.