Evaluation of 1cp-LSD for Enhancing Welfare in Shelter Dogs: A Randomized Blind Trial with Ethological Intervention.
Veterinary sciences January 19, 2026 Elisa Hernández-Álvarez, Cristina Canino-Quijada, Sira Roiz et al.
Giving shelter dogs a low dose of 1cp-LSD (a legal LSD-like compound) alongside behavioral therapy improves their sociability, calmness, and positive emotional reactivity more than either treatment alone. Twenty dogs were randomly assigned to receive the drug, ethological intervention, both, or neither. The combined treatment produced benefits that lasted for three weeks after the sessions ended. These results offer early evidence that integrating low-dose psychedelics with behavioral therapy could help reduce stress and anxiety in shelter dogs, though larger studies are needed to confirm safety and effectiveness.