Unit of Toxicology, Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe s/n, 35016 Las Palmas de Gran Canaria, Spain.
2 papers in the library · 1 citation · publishing 2025-2026
A proposed study will test whether low doses of 1cp-LSD, a legal LSD analogue, can help manage chronic pain in dogs with osteoarthritis. About 24 dogs will receive intermittent, sub-perceptual doses of the drug or a placebo over 30 days while continuing standard pain medication. Caregivers will not know which treatment their dog receives. Pain will be measured using the Canine Brief Pain Inventory and caregiver reports, including a questionnaire on treatment expectations. The study expects pain scores to decrease in treated dogs, possibly influenced by caregiver expectations. Limitations include a small sample size and lack of established dosing.
Giving shelter dogs a low dose of 1cp-LSD (a legal LSD-like compound) alongside behavioral therapy improves their sociability, calmness, and positive emotional reactivity more than either treatment alone. Twenty dogs were randomly assigned to receive the drug, ethological intervention, both, or neither. The combined treatment produced benefits that lasted for three weeks after the sessions ended. These results offer early evidence that integrating low-dose psychedelics with behavioral therapy could help reduce stress and anxiety in shelter dogs, though larger studies are needed to confirm safety and effectiveness.