Psychedelics as Novel Therapeutics for Chronic Pain in Veterinary Medicine: A Hypothesis-Driven Protocol Using Low-Dose 1-Cyclopropionyl-D-lysergic Acid Diethylamide (1cp-LSD) in Canine Osteoarthritis.
Animals : an open access journal from MDPI December 19, 2025 Elisa Hernández-Álvarez, Andrea Acosta-Dacal, Octavio P Luzardo et al. 1 citation
A proposed study will test whether low doses of 1cp-LSD, a legal LSD analogue, can help manage chronic pain in dogs with osteoarthritis. About 24 dogs will receive intermittent, sub-perceptual doses of the drug or a placebo over 30 days while continuing standard pain medication. Caregivers will not know which treatment their dog receives. Pain will be measured using the Canine Brief Pain Inventory and caregiver reports, including a questionnaire on treatment expectations. The study expects pain scores to decrease in treated dogs, possibly influenced by caregiver expectations. Limitations include a small sample size and lack of established dosing.