When mood and time align: nasal esketamine reduces lived time disturbances in treatment-resistant depression.
International journal of psychiatry in clinical practice July 10, 2025 Stefan Jerotic, Milica Nestorovic, Janko Nesic et al. 3 citations
In two male patients with treatment-resistant depression, a structured interview assessing their felt sense of time (TATE) detected improvements in subjective experience before a standard depression rating scale (MADRS) did. One patient's TATE scores reached general population levels at week 4, one week earlier than the MADRS indicated treatment response. These cases suggest that phenomenological assessments can capture nuanced early improvements that traditional scales may miss, offering a complementary tool for monitoring treatment effectiveness.