Psilocybin treatment extends cellular lifespan and improves survival of aged mice
npj Aging July 8, 2025 Kosuke Kato, Yoon-Joo Shin, Cristian Coarfa et al. 11 citations
Psilocybin, the psychedelic compound from hallucinogenic mushrooms, is known for therapeutic potential in psychiatric and neurodegenerative conditions, but its molecular mechanisms are unclear. This study provides the first experimental evidence that psilocin, the active metabolite of psilocybin, extends cellular lifespan, and psilocybin treatment promotes increased longevity in aged mice. These findings suggest psilocybin may be a potent geroprotective agent, opening new avenues for aging research.