Neuron
May 1, 2022
J. Lopez, M. Lücken, E. Brivio et al.
78 citations
A single low dose of ketamine produces a rapid and lasting antidepressant effect in mice, but the molecular mechanisms are unclear. This work identifies Kcnq2 gene activity in glutamatergic neurons of the ventral hippocampus as a key regulator of ketamine's sustained action. Combining ketamine with retigabine, a KCNQ activator, enhanced antidepressant-like effects, an effect not seen with the classical antidepressant escitalopram. These findings advance understanding of ketamine's sustained antidepressant mechanisms and suggest potential clinical applications.
Science advances
July 11, 2025
Lujuan He, Xuenan Wang, Shilin Luo et al.
8 citations
Arketamine, the (R)-enantiomer of ketamine, produces faster and longer-lasting antidepressant-like effects than esketamine in mice subjected to chronic social defeat stress. Activating the proteins CREB and MeCP2 drives the production of brain-derived neurotrophic factor (BDNF) in microglia, the brain's immune cells. This microglia-derived BDNF strengthens excitatory synaptic transmission in the infralimbic region of the medial prefrontal cortex (mPFC). It also activates mPFC neurons that project to the nucleus accumbens (NAc) shell, a brain area involved in reward and mood. These mechanisms together underlie arketamine's antidepressant-like effects, highlighting the essential role of microglial BDNF in modulating this neural pathway.
Frontiers in Psychology
February 25, 2026
Natalie L. Dyer, Meredith Sprengel, Ivo V. Stuldreher et al.
A feasibility study monitored 23 adults with multiple sensors during guided loving kindness meditation and breathwork. Biofield measures changed as expected for some participants. After meditation, participants reported lower arousal and increased control, boundarylessness, and non-duality. After breathwork, participants reported increased arousal and decreased boundarylessness, connectedness, and non-duality. Strong correlations (r > 0.5) appeared between ultraweak photon emission from both hands, and moderate correlations (r > 0.4) between infrared nose temperature and left hand ultraweak photon emission. The authors conclude that simultaneous multi-sensor monitoring is feasible and that meditation and breathwork produce nearly opposite effects, but larger samples and control groups are needed.