Understanding the Experience of Ketamine-Assisted Therapy and the Importance of Context.
Journal of psychoactive drugs July 2, 2025 Grace Stockwell, Nicholas R Hoeh, Francesca Fogarty et al. 2 citations
In-depth interviews with 12 people receiving ketamine-assisted therapy for treatment-resistant depression reveal that preparation of mind-set—including openness, clear intentions, mindfulness, and understanding how the therapy works—supports therapeutic benefit. Comfort in the setting, fostered by learning about the therapist's personal experiences, a strong therapeutic alliance, and feeling safe, helps patients 'let go.' External cues like music can guide a spiritual journey. Caution is warranted when trauma surfaces and letting go leaves patients feeling vulnerable. These contextual processes inform future clinical trials and improve the efficacy of ketamine-assisted therapy.