Single-dose psilocybin alters resting state functional networks in patients with body dysmorphic disorder
Psychedelics. September 24, 2024 Xi Zhu, Chen Zhang, David J. Hellerstein et al. 6 citations
A single 25 mg dose of psilocybin, given with psychological support, led to significant reductions in body dysmorphic disorder symptoms at one week and twelve weeks after dosing in eight adults with moderate-to-severe nondelusional BDD. Resting state functional connectivity measured one day after dosing showed increased connectivity within the Executive Control Network and between the Executive Control Network, Default Mode Network, and Salience Network. These connectivity increases predicted symptom improvement at one week. The authors note the small sample size and uncontrolled design require larger controlled studies to validate the findings.