Brain communications
January 1, 2024
Ashley Ghaw, Alisha Chunduri, Arnold Chang et al.
13 citations
Lysergic acid diethylamide (LSD) produced a dose-dependent increase in negative blood oxygen level-dependent (BOLD) signal, indicating decreased brain activity, in awake rats. The most affected regions were the primary olfactory system, prefrontal cortex, thalamus, and hippocampus. Contrary to the hypothesis that LSD would increase activity in the prefrontal cortex and thalamus while decreasing hippocampal activity, the results showed an acute decrease in activity across these areas. However, functional connectivity increased between the thalamus and somatosensory cortex, and between the cerebellar nuclei and surrounding brainstem areas. The enhanced thalamus-sensorimotor connectivity aligns with human studies, while the unexpected increase in cerebellar nuclei connectivity raises questions about its role in hallucinogenic effects.
Scientific reports
August 11, 2024
Lila Harris-Blum, Zachary Smith, Richard J Ortiz et al.
9 citations
Exposure to LSD during periadolescence in mice altered gray matter microarchitecture across much of the brain, particularly in the thalamus, sensory and motor cortices, and basal ganglia, while the forebrain olfactory system, prefrontal cortex, and hindbrain were unaffected. Multiple doses reduced functional connectivity between forebrain white matter tracts and sensorimotor cortices and hippocampus. However, no differences in brain volume, cognitive performance, or motor behavior were observed when the animals were tested as young adults. The pronounced changes in diffusion-weighted imaging values across 74 brain areas suggest altered neuroplasticity, but the behavioral consequences of the connectivity changes remain unknown.
Frontiers in Neuroscience
May 1, 2025
Evan Fuini, Arnold Chang, Josh Edwards et al.
6 citations
Psilocybin, a hallucinogen, produces dose-dependent increases in brain activity in awake rats, particularly in the somatosensory cortex, basal ganglia, and thalamus. Female rats showed greater activation than males at the 0.3 mg/kg dose in thalamic and basal ganglia regions. The drug also caused a global increase in functional connectivity, especially hyperconnectivity to the cerebellum. Higher doses activated circuits involved in sensory filtering and motor organization, such as the cortico-striato-thalamo-cortical circuit and claustrum. However, the direction of BOLD signal changes and neural network activity patterns differed from those reported in human studies.