Protocols and practices in psilocybin assisted psychotherapy for depression: A systematic review.
Journal of psychiatric research August 1, 2024 Noah Chisamore, Danica Johnson, Margery J Q Chen et al. 21 citations
Psilocybin-assisted psychotherapy shows promise for treating depression and distress in life-threatening illnesses, but a systematic review of 28 clinical trial protocols reveals substantial variability and inconsistency in therapeutic approaches beyond the basic framework of preparatory, dosing, and integration sessions. The review found no validated or universally agreed-upon protocol, with frequent lack of clarity in descriptions of therapy models, duration, and number of sessions. Future studies need to define and report psychotherapeutic components more clearly to identify the safest and most effective approaches.