Biological psychiatry
January 1, 2024
Elizabeth A Hoge, Caroline H Armstrong, Mihriye Mete et al.
10 citations
Anxiety disorders are linked to heightened startle responses during unpredictable threat, a physiological marker called anxiety-potentiated startle (APS). In a study of 93 individuals with anxiety disorders and 66 healthy controls, APS was higher in the anxious group at baseline. After eight weeks of treatment with either escitalopram or mindfulness-based stress reduction, both treatment groups showed significantly greater reductions in APS compared to controls, with patients' APS levels falling into the range of healthy individuals. Fear-potentiated startle (FPS), a response to predictable threat, did not differ between groups at baseline nor change with treatment. These results validate APS as a biological correlate of pathological anxiety and provide evidence that mindfulness-based stress reduction can alter anxiety-related neurocircuitry similarly to medication.
Journal of mood and anxiety disorders
March 1, 2025
Diane Joss, Michael Datko, Charisma I Washington et al.
5 citations
Self-judgment, a symptom common to many psychological disorders, often follows childhood maltreatment and can make standard treatments less effective. In a pilot study of 24 adults with anxiety or depressive disorders (83% had multiple diagnoses), an eight-week mindful self-compassion program significantly reduced self-judgment and increased self-compassion. Participants who reported more childhood trauma improved more than those with less trauma. Brain scans showed that reduced self-judgment was linked to stronger connections between the posterior cingulate cortex and frontal regions involved in regulation and language, and weaker connections with the amygdala-hippocampal complex, suggesting the training lessens fear-related influences on self-referential thinking while boosting executive control.
Journal of mood and anxiety disorders
June 1, 2024
Danielle Moskow Diamond, David Rosenfield, Nikki Kaiser et al.
5 citations
In generalized anxiety disorder, different treatments improve distinct aspects of mindfulness. A clinical trial randomly assigned 226 individuals with GAD to 12 weeks of Kundalini Yoga, cognitive behavioral therapy, or stress education. The Non-judge, Act with Awareness, and Non-react facets of mindfulness increased significantly during treatment, while the Observe and Describe facets did not. Improvement in Acting with Awareness was significantly greater for Kundalini Yoga than for cognitive behavioral therapy. These findings suggest that behavioral treatments can influence specific mindfulness components differently.
Journal of affective disorders
September 1, 2025
Elizabeth A Hoge, Mihriye Mete, Amanda W Baker et al.
3 citations
For adults with anxiety disorders, Mindfulness-Based Stress Reduction (MBSR) delivered via videoconference was comparably effective to in-person MBSR, but MBSR-VC did not meet the threshold for non-inferiority compared to the antidepressant escitalopram (ESC) delivered by videoconference. In a randomized controlled trial with 202 participants, MBSR-VC and ESC-VC showed similar average improvement on the Clinical Global Impression of Severity scale (1.39 vs 1.51 points), but non-inferiority was not supported. In-person treatments had a greater impact on social anxiety than their video versions. ESC-VC received higher satisfaction ratings and had a greater effect on panic symptoms than MBSR-VC. Remotely delivered MBSR is a viable option for anxiety disorders, though social anxiety may benefit more from in-person care.
Neuroscience letters
May 23, 2025
Diane Joss, Gunes Sevinc, John W Denninger et al.
1 citation
Among 94 chronically stressed but otherwise healthy adults randomized to eight weeks of meditation, yoga, or stress education, only the meditation group showed a significant reduction in resting-state functional connectivity between the posterior cingulate cortex and the left hippocampus. Changes in this brain connectivity were correlated with improvements in perceived stress, allostatic load, and anti-inflammatory gene expression, suggesting that meditation's neural effects are closely linked to physical wellness biomarkers. No such changes occurred in the yoga or stress education groups, indicating this neurobiological mechanism may be unique to meditation training.