Untargeted analysis of psilocybin and non-psilocybin mushrooms using liquid chromatography quadrupole time of flight mass spectrometry.
Journal of chromatography. A July 19, 2025 Sabrina Islam, Tiffany Liden, Roman Goff et al. 1 citation
Psilocybin mushrooms, which contain psychoactive compounds like psilocybin and psilocin, are being studied for treating psychological disorders. An untargeted chemical analysis using liquid chromatography and mass spectrometry compared the chemical diversity of several psilocybin mushroom species to edible non-psilocybin mushrooms. The analysis identified multiple classes of compounds and their derivatives. Principal component analysis showed that psilocybin mushrooms and non-psilocybin mushrooms are compositionally very different from each other. These findings deepen understanding of the chemical complexity of psilocybin mushrooms and provide a foundation for future research into their medical and psychological applications.