A man with alcohol use disorder (AUD) maintained sobriety while taking an SSRI and naltrexone, but stopped the SSRI to take part in a psilocybin ceremony, after which he relapsed to alcohol use. The case examines factors that likely contributed to the relapse, including the discontinuation of the SSRI, the context of the psilocybin experience, and the absence of structured follow-up care.
In the 1950s and 1960s, researchers at the Mayo Clinic conducted studies with psychedelic drugs, including LSD and psilocybin. Their work sometimes prioritized scientific advancement over the rights and safety of participants, raising ethical concerns about informed consent and equitable treatment. These historical problems continue to challenge contemporary psychedelic research.