Psychoactive substances: novel molecular insights and therapeutic potential for Alzheimer's disease.
Translational neurodegeneration July 25, 2025 Chonglei Fu, Xuehui Li, Xiaoxing Liu et al. 2 citations
Alzheimer's disease causes severe cognitive decline and lacks effective treatments to halt neurodegeneration or promote neuronal repair. Psychoactive substances, including central nervous system depressants and stimulants, cannabinoids, psychedelics, opioids, and ketamine, are being explored for their abilities to enhance learning and cognitive performance and potential neurorestorative functions. This review examines the molecular mechanisms and therapeutic potential of these compounds in Alzheimer's disease, aiming to guide future research directions.