Department of Anaesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, Henan University People's Hospital, Zhengzhou, Henan, 450000, China.
A simplified, app-based mindfulness program for people with epilepsy in mainland China was feasible and well-accepted. Ten adults completed a 6-week self-guided program (15 minutes daily, 6 days per week) via a WeChat mini-program. Completion rates averaged 110.1%, and user feedback was positive. Exploratory assessments suggested improvements in quality of life (median increase of 9.12 points on the QOLIE-31) and reductions in anxiety (median decrease of 5.50 points on the GAD-7). Seizure frequency descriptively decreased by a median of 1.17 seizures per 4 weeks, with half of participants experiencing at least a 50% reduction. These findings support planning a future randomized controlled trial.
A single intravenous dose of esketamine (0.25 mg/kg) given at the start of surgery reduces postoperative anxiety in adolescents aged 13–18 years, with lower anxiety scores on days 1, 3, 7, and 14 after surgery. Depression scores were lower only on day 14. The drug did not significantly change inflammatory markers (CRP and IL-6) or cause more adverse events than placebo. Esketamine was a protective factor against postoperative anxiety (odds ratio 0.38). The findings suggest a safe, short-term benefit for anxiety, with limited effect on depression, in this age group.